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Assessment Help Tem, We need help from a biological medical background or someone in Molecular Oncology. I want to write an approximately 5500 words. Please go through all the point 1- The topic: Radiation-Induced Secondary Malignant Neoplasms: Physics Meets Biology 2- References: 45 or more in Harvard style 3- I going to help with update References day by day 4- The core of this review paper is my literature review which I`m going to attach to you with all the References note please I have not published yet so do not want any plagiarism between the two (I trust you honestly) Please also make the review paper synchronize with my literature review. 5- The idea of the review paper: could we apply the functional assay (specifically y-H2AX assay) on a patient who diagnoses with cancer or Secondary Malignant Neoplasms and has a sensitive result could help the clinician to start the Radiation therapy or non-start or modify the mechanism of the treatment or have a new plan. What is the challenging that we will face with that? 6- The structure of the review paper: A- introduction about the topic (Radiation-Induced Secondary Malignant Neoplasms: Physics Meets Biology) please I want it for someone who very well-known about the topic, not something general and we need to mention about the physical side please. b- 1st body paragraphs about: the genetic basic of the Radiosensitivity which includes role of genetic predisposition, DNA repair, cell-cycle, and cell-death regulation, a role of DNA Damage Response (DDR), radiotherapy alters gene expression, DNA repair genes result in increased radiosensitivity and also other genomic mechanisms. c- 2nd body paragraphs about: Use of the γ-H2AX-Based Assay to Monitor DNA Repair Efficiency in Primary Cells (this is the functional assay) which involved in many studies (see the Literature analysis_update) and we need to speck also about the whole genome sequencing for each patent and how that will cost a lot of money and if can mention another test please. d- the concluding very important we want the paper to be for a highly professional audience with high quality please My supervisor is Olga A. Martin so please include all of her work I attached to you • Literature analysis_update • my literature review • my literature review References • some References for Radiation-Induced Secondary Malignant Neoplasms: Physics Meets Biology and we will update soon if I find something but also help us with very good paper if you can please I appreciate all your helps Best Regards, Mohammad
