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Use Meta-analysis jounals to gather literetaure and evidence

01 / 10 / 2021 Essays

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Brief review of Johnson and Johnson lawsuits
Use Meta-analysis jounals to gather literetaure and evidence
find the connection between talcum powder and ovarian cancer and other associated cancers
use examples of ramdomised experiments
risk factors associated with talcum powder, the time scales, thus progression of the cancer over life time use?
connection between absestos talcum *banned* and absestos free taclum? Lack of in vitro studies which test whether talc causes cancer e.g. tissue culture using ovarian cell lines and adding talc powder to see whether cells become cancerous.

useful info:

• Jacky Fox claimed that she used talc powder for many years. She was born in 1953 and died in 2015 when she was 62 years old.
Positive notion that asbestos is linked with ovarian cancer [1]
• Asbestos containing talc was banned in 1970s. There is a possible link that she was using asbestos containing talc powder while being young and therefore eventually got cancer later in her life due to asbestos.
Can we trust the word of Johnson & Johnson?
•J&J had similar case with formaldehyde which is known carcinogen. J&J had to remove formaldehyde from baby shampoo due to California safety regulations, consumers’ and activists’ pressure. (formaldehyde national toxicology program (2012) 12ed.)
•Under the Federal Food, Drug and Cosmetic Act (FD&C Act), cosmetic products and ingredients, with the exception of color additives, do not have to undergo FDA review or approval before they go on the market.
•2016 study; 2000 cases shows possible risk. Asbestos-free talc. https://journals.lww.com/epidem/Citation/2016/05000/The_Association_Between_Talc_Use_and_Ovarian.6.aspx
Questions:
•Most ovarian cancers are detected at late stage and have poor prognoses. How do we know if talc is a causative agent if early stage ovarian cancer can’t be detected?
•Promotes progression at late stage?

reference to also include
[1] Does Exposure to Asbestos Cause Ovarian Cancer? A Systematic Literature Review and Meta-analysis
•Alison Reid, Nick de Klerk and Arthur W. (Bill) Musk •DOI: 10.1158/1055-9965.EPI-10-1302 Published July 2011
•[2]
Epidemiology. 2016 May; 27(3): 334–346. Published online 2016 Apr 1. doi: 10.1097/EDE.0000000000000434 PMCID: PMC4820665
The Association Between Talc Use and Ovarian Cancer
A Retrospective Case–Control Study in Two US States



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