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01 / 10 / 2021 Medical

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The title "Emerging virus pseudotypes". In this you should cover: 1) Ebolaviruses (including Marburg) 2) Coronaviruses (specifically SARS and MERS) 3) Nipah virus and Hendra virus 4) Rabies virus and lyssaviruses You should search the literature for primary research papers where these viruses have been pseudotyped and make note of what viral core was used. This is normally: 1) HIV or 2) Murine leukemia virus or 3) Vesicular stomatitis virus You should then determine if either of these cores confers an advantage, focus on the amount of virus produced, e.g. virus titre. Note any other major advantages or disadvantages, e.g. how the viruses behave in downstream assays. What applications the pseudotyped viruses have been used for, e.g. studies on antigenic sites/epitopes. The guidance above is not exhaustive i.e. you can cover additional viruses and discuss what assays different cores are used for etc.

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