This paper circulates around the core theme of 1. The basic pharmacology of tacrolimus (including the mechanism(s) of action and toxicities/adverse effects), its clinical uses and dosages/formulations available. together with its essential aspects. It has been reviewed and purchased by the majority of students thus, this paper is rated 4.8 out of 5 points by the students. In addition to this, the price of this paper commences from £ 99. To get this paper written from the scratch, order this assignment now. 100% confidential, 100% plagiarism-free.
Case Study 4 – Tacrolimus (Presentation time = 20-25 minutes)
XY is a 50-year-old. 75-kg (height 178cm) male renal transplant patient 2 days after his transplant surgery. His liver functions tests are normal. Suggest an initial oral tacrolimus dose designed to achieve a steady state tacrolimus blood concentration equal to 15 ng/ml. Calculate the peak and trough tacrolimus blood concentrations at steady state.
In your group presentation, you must discuss:
1. The basic pharmacology of tacrolimus (including the mechanism(s) of action and toxicities/adverse effects), its clinical uses and dosages/formulations available.
2. The chemical structure/characteristics of tacrolimus related to its interesting pharmacokinetic characteristics and the clinical implication of these unique features.
3. Considerations that you need to factor in while using tacrolimus in special populations (in renally or hepatically impaired, or in obese patients).
4. Resolve the case study, showing all calculations/steps to determine your answer.