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• apply critical thinking by evaluating primary literature including clinical trials, and systematic reviews (qualitative, or quantitative ‐ meta– analysis), and

18 / 01 / 2019 Pharmacy

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Pharmacotherapeutics

 

Students will

 

• apply critical thinking by evaluating primary literature including clinical trials, and systematic reviews (qualitative, or quantitative ‐ meta– analysis), and

 

 • synthesise their findings into a review‐like document

 

Assignment Details In this assignment you will

 

1. Conduct a literature review of the hepatitis C condition (epidemiology, pathophysiology, symptoms, diagnosis, treatment, prognosis, etc) using self‐selected resources. Use this as an introduction to the condition of hepatitis C in your review document.

 

 2. Conduct a literature review on ledipasvir and sofosbuvir (Harvoni) and an additional drug of your choosing with regards to their safety & effectiveness and place in current clinical practice in the management of hepatitis C. 3. Critically appraise (a template will be provided) clinical trials (3 to 6 in number) for their quality (internal & external validity) for a) ledipasvir and sofosbuvir (Harvoni) in hepatitis C treatment

 

• Critical appraisal of the clinical evidence includes checking for – Internal and external validity, and – Strength of evidence of your research articles

 

• Level (place in research hierarchy) – more later

 

• Quality (risk of bias) •

 Need to demonstrate that you have undertaken the above & have an understanding of the co

ncepts in your assignment



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